What is it?
The MDR1 gene defect is a hereditary disease that leads to drug hypersensitivity. The MDR1 gene defect is a defect in the MDR1 gene that can occur in some dog breeds and also in humans. It is suspected that the cause of the defect in dogs is a single animal that played a key role in establishing the Collie breed around the time of the 19th century. This genetic defect is therefore also occurring more frequently today in dogs that belong to the herding dog breed or that carry it genetically.
This genetic disease leads to a deficient or lacking synthesis of a certain protein (P-glycoprotein), which is an important component of the blood-brain barrier. The so-called MDR1 transporter forms a protective barrier for the brain at this boundary between the brain blood vessels and the cranial nerve tissue. The transporter is located as part of the blood-brain barrier on the surface of the endothelial cells (cells that line the walls of the blood vessels).
It protects the brain from toxins and drugs. In an animal with an MDR1 defect, the transporter is missing and protection is absent. As a result, severe brain and nerve damage can occur after the administration of certain substances, which can lead to death.
Which breeds are affected?
The MDR1 gene defect primarily affects herding dogs such as Collies, Border Collies, Australian Shepherds, Shetland Sheepdogs.
3 genotypes
The first possibility is that the MDR1 is (+/+), which means the animal is free of the defect and can produce the necessary protein just like any other breed. All substances can be administered here. The second possibility is that the animal has the MDR1 (+/-) genotype, meaning it was inherited heterozygous (one of two alleles is affected). The defect was only inherited from one parent and can be passed on. Side effects may occur when taking unwanted medication, but this is not inevitable. Dogs with this possibility should be treated like dogs that are MDR1 (-/-).
The third possibility is that the MDR1 is (-/-), which means the animal is homozygous for the defect (both alleles are defective). A functional MDR1 transport system is missing. The defect was inherited from both parents and will certainly be passed on. Certain substances must be avoided during therapy.
How can I determine whether my animal is affected?
Externally, affected dogs cannot be distinguished from healthy ones. In order to find out whether a dog is a carrier of the genetic defect, a genetic test must be carried out in a special laboratory. For this purpose, approximately 1 ml of blood is taken from the dog once.
What happens with such a genetic defect?
Since the protective mechanism for the blood-brain barrier is missing in an MDR1 genetic defect, these substances can enter the nervous system and accumulate there. The result is severe symptoms of poisoning, which can lead to death. Dogs with an MDR1 genetic defect can suffer side effects (depending on the active ingredient, from harmless to life-threatening) from many different active ingredients in medications even at normal doses, i.e. what is actually supposed to help can torment them and sometimes poison them fatally. Symptoms can include vomiting, disorientation, movement disorders, tremors, increased panting, unusual behavior (e.g. stress), etc.
Which substances are affected?
The intolerance affects both everyday medications prescribed by a veterinarian, such as certain antiparasitics (worming treatments, flea and tick repellents) or gastrointestinal medications, as well as certain antibiotics, heart medications, painkillers, anesthetic/sedative and emergency medications, and chemotherapy drugs, which are generally completely unproblematic for healthy dogs. Dogs should also be careful not to ingest horse manure when walking, as the horses could have been treated with an antiparasitic drug. The amount excreted here could trigger intolerance in a dog with the MDR1 gene defect.
Is CBD one of these substances?
CBD can also pass through the blood-brain barrier. It is suspected that it can cause severe brain poisoning in dogs with the genetic defect. However, more precise details are not yet known, as appropriate studies are still lacking. Therefore, you should refrain from administering CBD oil if you know or suspect that you have an MDR1 genetic defect.
What should I take instead?
CBD is often used by pet owners to calm down or relieve pain. Alternative to the effects of CBD: Joint support ArthroGreen Classic (item no. 285) is ideal for preventing diseases that affect the musculoskeletal system. ArthroGreen plus (item no. 554) is characterized by an additional portion of willow bark, which is said to have a pain-relieving effect in naturopathy.
Calming
In order to provide long-term support to stressed dogs in everyday life, the nerve food (item no. 358) was designed from plants with a calming healing effect. Bach flowers are a popular remedy for dealing with fear, inner restlessness, stress and other negative mental states. (Bach flowers S.O.S item no. 4166) Calma (item no. 2032) ensures relaxation in acute stress situations.
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Content: 0.4 Kilogramm (€29.88 / 1 Kilogramm)
Fit-BARF BM-Yeast consists of brewers' yeast bound to malt rootlets. Brewers' yeast contains biotin, folic acid, iron, zinc, and trace elements, which have a positive influence on the condition and resistance of skin and hair. The nutrition-related regenerative capacity of individual cells can also be influenced. Malt rootlets are characterized by their content of easily digestible carbohydrates, crude fiber, and crude protein. Due to their high crude fiber content, germ buds also have a good dietary value.
Content: 0.6 Kilogramm (€18.25 / 1 Kilogramm)
The proportion of animal fat should be 15-25% in the diet of the dog and the cat should be at about 10%. If your dog or cat is fed with lean meat, it uses proteins to produce energy. In this case, wastes will be generated that need to be digested by liver and kidneys. The strain on the metabolism increases. On the long term, this can lead to congestions of the excretory organs. In case of dogs or cats that are poorly using the feed or very underweight, special attention should be paid to the fat content of the meat.
Content: 0.5 Liter (€33.90 / 1 Liter)
Brewers' yeast, as the most balanced, natural source of vitamin B, whose vitamins are present in a broken down state and can be absorbed directly, is a valuable addition to the daily diet. In addition, brewers yeast has a positive effect on the intestinal flora. Its content of phosphorus, potassium, magnesium, calcium, iron, zinc, copper, and manganese, as well as the trace elements cobalt, molybdenum, chromium, and selenium, provide an important contribution to demand-oriented nutrition.
Content: 0.2 Kilogramm (€54.75 / 1 Kilogramm)
Fit-BARF Cod Liver Oil is a high-value supplier for omega-3-fatty acids and vitamin D. Omega-3-fatty acid (for example linolenic acid) are polyunsaturated fatty acids, which cannot be created itselves by the body. Thus they are called essential and must be fed to the organism with the nutrition. Vitamin D is important for the builing of the bones and the regulation of the calcium balance.
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Calcium intake, in particular, plays a major role in the feeding of raw meat. This can only be achieved by feeding sufficient bone. Not every dog can or wants to eat bones, and in the case of cats, feeding whole prey (mice or chicks) is not always problem-free either.Fit-BARF Eggshell Powder is a readily utilizable animal source of calcium for daily feeding. It provides balance when feeding raw meat by balancing the high phosphorus content of the meat with its natural calcium content. Due to the fine degree of grinding, the product has a high bioavailability.neutralization of phosphorus excess with predominant meat feedingfor bone-free feedingas an extra source of calcium in times of increased demand (growth, gestation, lactation)
Content: 0.3 Kilogramm (€36.50 / 1 Kilogramm)
Fit-BARF Feeding Oil is a mixture of high-grated cold-pressed vegetable oils. Cold-pressed, food-grade linseed oil forms the basis of this purely natural feeding oil. This admixed functional oils (evening primrose oil, wheat germ oil, pumpkin seed oil and argan oil) ensures the optimal, well-balanced maintenance with essential fatty acids. Through this combination of pure naturally ingredients Fit-BARF Feeding Oil is a high-concentrated energy source and similarly an origin of significant vital substances of selected oils in one product.
Content: 0.1 Liter (€89.50 / 1 Liter)
Fit-BARF Fruit is made from selected ingredients to enable a well-balanced nourishment with feeding. It complements the requirement of vitamins (Niacin, Riboflavine (B2), folic acids, E, A, K, C), flavonoids (polyphenols) as well as fiber.Fit-BARF Fruit is free of grain and a healthy alternative to vegetables. It does not bring only variety, but also a balance in the BARF feeding plan. In combination with Fit-BARF MicroMineral, the basis is thus laid for healthy raw feeding.
Content: 0.1 Kilogramm (€109.50 / 1 Kilogramm)
Feed material (powder) for dogs and catsNatural source for taurine and glycosaminoglycans – for the demand-oriented provision at feeding with raw meatThe naturally very high taurine content of the greenshell mussel is a very pleasing aspect for cat owners. Cats in particular depend on a sufficient supply of this organic acid in their food, as they cannot produce taurine themselves and lose a large part of it through their excretions. Taurine is essential for cats. A deficiency can lead to severe impairments and physical damage.Fit-BARF Greenshell Mussel consists of New Zealand greenshell mussel powder (Perna canaliculus, freeze-dried, non-defatted mussel meat). In addition, the greenshell mussel provides important components of the body's own mucous membrane as a building block and can thus have a supportive effect on the functionality and elasticity of the urinary bladder and all other mucous membranes. Occasionally fed, the trace elements and vitamins contained in the greenshell mussel can have a positive effect on vitality, metabolism, nutritional imbalances and on stressed skin.Expert tip: Does your dog suffer from joint problems? Then take a look at ArthroGreen Classic. The herbal composition, proven for years, supports your beloved four-legged friend on his daily tours.Growing puppy? Here ArthroGreen Junior offers the nutrients for a safe step into the big, wide world.Composition: New Zealand greenshell mussel powder (Perna canaliculus, freeze-dried, non-defatted mussel meat) 100%Analytical constituents: crude protein 54,1%, crude fat 10,3%Feeding recommendation: Add daily to the feed. Cats: 0.5 g/5 kg body weight. Dogs: 0.5 g/10 kg body weight. 1 half tsp. corresponds to ca. 1.5 g.
Content: 0.035 Kilogramm (€455.71 / 1 Kilogramm)
